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TLS Online TPP Program

#Question id: 12185

Mitotic CDKs affect nuclear envelope components by specific mechanism. Which of the following statement is not related to this mechanism?

#Unit 2. Cellular Organization
  1. The CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate into subcomplexes during prophase. 
  2. Phosphorylation of integral membrane proteins of the inner nuclear membrane causes depolymerization of the lamin intermediate filaments.
  3. The weakening of the associations between the inner nuclear membrane proteins and the nuclear lamina and chromatin allows sheets of inner nuclear membrane to retract into the endoplasmic reticulum, which is continuous with the outer nuclear membrane.
  4. Mitotic CDKs induce the formation of the mitotic spindle. The function of the mitotic spindle is to segregate chromosomes so that the sister chromatids separate from each other and are moved to opposite poles of the cell.
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TLS Online TPP Program

#Question id: 15302

#Unit 5. Developmental Biology

FOXP1 is a transcription factor which stimulate the production of Oct4 and Nanog and establish pluripotency. Which of the following statements are correct regarding to the mechanism of alternative splicing of FOXP1. 
A. There are two isoforms of the FoxP1 protein, One is the product of an mRNA spliced to include a particular exon, 18b, while the other splicing variant carries exon 18a.
B. When alternative splicing generates a form including exon 18b in place of 18a, the resulting isoform (FOXP1-ES) binds to a different DNA sequence and thus controls expression of a different set of genes.
C. The protein encoded by the exon 18b– carrying mRNA is called FOXP1-ES it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation. 
D. The exon 18a– containing form encodes FOXP1 itself, and this has the opposite effect: this activates genes that promote dedifferentiation, and thus stimulates iPS cell formation.
TLS Online TPP Program

#Question id: 15391

#Unit 5. Developmental Biology

In the initiation of the vertebrate eyes, paired regions of the brain bulge out and approach the anterior region of -------germ layer:
TLS Online TPP Program

#Question id: 15392

#Unit 5. Developmental Biology

If an optic vesicle from a Xenopus laevis embryo is placed underneath head ectoderm in a different part of the head from where the frog’s optic vesicle normally occurs then what happens?
TLS Online TPP Program

#Question id: 15393

#Unit 5. Developmental Biology

First inducers (in early gastrula stages) of the lens may be:
TLS Online TPP Program

#Question id: 15394

#Unit 5. Developmental Biology

The elongation and curvature of the lens fibers control by:
TLS Online TPP Program

#Question id: 15395

#Unit 5. Developmental Biology

Which of the following promote the synthesis of the Paired box 6 (Pax6) transcription factor in the anterior ectoderm?