TLS Online TPP Program
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TLS Online TPP Program
#Question id: 14686
#Unit 4. Cell Communication and Cell Signaling
This member of the AKAP family, designated mAKAP, anchors both PDE and the regulatory subunit of PKA to the nuclear membrane, maintaining them in a negative feedback loop that provides close local control of the ATP level and PKA activity.
B- The basal level of PDE activity in the presence of hormone (resting state) keeps cAMP levels below those necessary for PKA activation.
C- Activation of β-adrenergic receptors causes an increase in cAMP to a level in excess of that which can be degraded by PDE.
D- The resulting binding of cAMP to the R subunits of PKA releases the active catalytic (C) subunits into the cytosol. Some C subunits enter the nucleus, where they phosphorylate and thus activate certain transcription factors . Other C subunits phosphorylate PDE, stimulating its catalytic activity.
E- Active PDE hydrolyzes cAMP, thereby driving cAMP levels back to basal levels and causing re-formation of the inactive PKA C-R complex. Subsequent de-phosphorylation of PDE returns the complex to the resting state.
TLS Online TPP Program
#Question id: 19989
#Unit 2. Cellular Organization
Which of the following is correctly representing gene capacity of human if average gene size is 3000 base pairs
TLS Online TPP Program
#Question id: 33531
#Unit 2. Cellular Organization
The data obtained during DNA microarray analysis showing wildtype vs. mutant expression of genes under different conditions, represented as
TLS Online TPP Program
#Question id: 3664
#Unit 3. Fundamental Processes
If a mutation is complemented by a clone of a different gene whose product is being overproduced, this is called:
TLS Online TPP Program
#Question id: 28672
#Unit 2. Cellular Organization
Which proteins is involved to inhibit Cdc25 phosphatase and hold it into inactive condition