TLS Online TPP Program

#Question id: 12482


The Rb protein has been called the “master brake” of the cell cycle. How the Rb protein acts as a cell cycle brake?

#Unit 2. Cellular Organization
  1. Rb bound to E2F and function as transcriptional repressors because Rb recruits chromatin-modifying enzymes that promote deacetylation and methylation of specific histone lysines, causing chromatin to assume a condensed, transcriptionally inactive form.
  2. S phase CDKs and mitotic CDKs maintain Rb protein in the phosphorylated state throughout the S, G2, and early M phases.
  3. Rb bound to E2F and promotes ubiquitinylation of E2F and inhibits chromosomal segregation.
  4. Rb bound to E2F and promotes acetylation which prevents unloading of cohesins.