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TLS Online TPP Program

#Question id: 12836

The final layer of control that is critical in the regulation of CDKs is a family of proteins known as CDK inhibitors, or CKIs, which bind directly to the cyclin-CDK complex and inhibit its activity. Which of the following function not done by CKIs?

#Unit 2. Cellular Organization
  1. Binding of INK4s to CDK4 and CDK6 blocks their interaction with cyclin D and hence their protein kinase activity. 
  2. p27 prevents the premature activation of S phase CDKs during G1.
  3. p21CIP plays an important role in the response of metazoan cells to DNA damage by inhibiting G1/S phase CDKs and S phase CDKs, and thereby blocking entry into or passage through S phase.
  4. During ongoing DNA replication and in response to replication stress (slow DNA replication fork movement or DNA replication fork collapse), the ATR-Chk1 protein kinase cascade phosphorylates and inactivates Cdc25C, thereby preventing the activation of mitotic CDKs and inhibiting entry into mitosis.
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TLS Online TPP Program

#Question id: 7523

#General Aptitude

A, B and C are three participants in a kilometer race. If A can give B a start of 40 m and B can give C a start of 25 m, how many meters of a start can A give to C?
TLS Online TPP Program

#Question id: 7524

#General Aptitude

City X is at a distance of 560 km from City Y. A train starts from City Y to City X at 6 a.m. with a speed of 40 kmph. Another train starts from City X to City Y at 7 a.m. with a speed of 60 kmph. At what distance from City Y will the two trains be at the point of crossing?
TLS Online TPP Program

#Question id: 7525

#General Aptitude

A 100 m long train crosses a 200 m long and 20 m wide bridge in 20 second. What is the speed of the train in km/hr?
TLS Online TPP Program

#Question id: 7526

#General Aptitude

Walking from my home, at a speed of 5 km/h, I am 8 minutes late in reaching my office.If I walk at a speed of 8 km/h, I reach 5 minutes late. How far is my office from the house?
TLS Online TPP Program

#Question id: 7527

#General Aptitude

A train is running at a speed of 72 km/h . it crosses a platform whose length is half that of the train in 30 seconds. what is the length of the platform?
TLS Online TPP Program

#Question id: 7528

#General Aptitude

A 220 metres long train running at the speed of 110 kilometer per hour process another train running in opposite direction at the speed of 70 km per hour in 7 seconds. what is the length of the other train?