Practice Questions

TLS Online TPP Program

#Question id: 13142

The Norway rat (Rattus Norvegicus), a widespread pest, was controlled for about a decade by the anticoagulant warfarin. This chemical substance, placed in food pellets, is absorbed by the intestinal tract and inhibits the clotting of blood. After a population decline for about 10 years, rat populations increased and stabilized. In one European population, as illustrated in the graph below, the percentage of rats resistant to warfarin has remained fairly stable over a number of years.
Resistance to warfarin is governed by a dominant autosomal gene, R. More than 15 percent of the resistant animals are heterozygous at this locus (Rr). The table below indicates the response to warfarin and relative reproductive fitness of individuals that are homozygous or heterozygous for the dominant gene (R). The RR individuals have a 20-fold increase in vitamin K requirement over individuals.
Fitness is a measure of the reproductive success of a particular genotype. The highest fitness is 1.00.
There is a substantial number of heterozygotes in the population. Which of the following is the best explanation of this observation?

#Unit 10. Ecological Principles

Heterozygotes (Rr) have a selective advantage over both homozygotes (RR and rr).
The gene for susceptibility (r) is increasing rapidly each generation.
The gene for susceptibility (r) is being lost by chance each generation.
Dominant homozygotes (RR) enjoy a reproductive advantage over heterozygotes