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TLS Online TPP Program

#Question id: 13163

Following statements are regarding to the interaction between β2-adrenergic receptor and G- protein.

#Unit 4. Cell Communication and Cell Signaling
  1. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 5 and 6 and changes in the structure of the C3 loop; together, these changes create a surface that can bind to a segment of the Gα subunit and when unbound by ligand, the receptor has no surface that is complementary to the G protein and thus cannot bind to it.
  2. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 1 and 4 and changes in the structure of the C3 loop; together, these changes create a surface that can bind to a segment of the Gα subunit and when unbound by ligand, the receptor has no surface that is complementary to the G protein and thus cannot bind to it.
  3. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 5 and 6 and changes in the structure of the C3 loop; together, these changes have no surface that can’t bind to a segment of the Gα subunit and when unbound by ligand, the receptor creates a surface that is complementary to the G protein and thus can bind to it.
  4. Binding of ligand to the receptor induces major conformational changes in which there are substantial movements of transmembrane helices 3, 5, 6 and 7 and changes in the structure of the E2 loop; together, these changes create a surface that can bind to a segment of the Gα subunit and when unbound by ligand, the receptor has no surface that is complementary to the G protein and thus cannot bind to it.
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TLS Online TPP Program

#Question id: 10961

#Unit 7. System Physiology – Animal

Over the past 12 weeks, a 75-year-old man with a moderate aortic stenosis has developed shortness of breath and chest pains during exertion. He appears pale. Test of his stool for blood is positive. Laboratory studies show the following: hemoglobin 7.2 g/dL, and mean corpuscular volume 75. A blood smear shows microcytic, hypochromic erythrocytes. Which of the following is the most likely diagnosis?
TLS Online TPP Program

#Question id: 10962

#Unit 7. System Physiology – Animal

A 24-year-old man came into the ER with a broken leg. A blood test was ordered and his WBC count was 22 × 10^3/μl. Five hours later, a second blood test resulted in values of 7 × 10^3/μl. What is the cause of the increased WBC count with the first test?
TLS Online TPP Program

#Question id: 10963

#Unit 7. System Physiology – Animal

During an inflammatory response, which is the correct order for cellular events?
TLS Online TPP Program

#Question id: 10964

#Unit 7. System Physiology – Animal

A patient visits his dentist, who notices a sore on the patient’s lip. The sore was unusual in that there was no pain or drainage from the sore. The patient was subsequently admitted to the hospital with a violent shaking chill. His lab values were Hct 30%, platelets 400,000/μl, WBC 4200/μl, 68% lymphocytes, and 20% neutrophils. What is the diagnosis of this patient?
TLS Online TPP Program

#Question id: 10965

#Unit 7. System Physiology – Animal

Which of the following is a TRUE statement?
TLS Online TPP Program

#Question id: 10966

#Unit 7. System Physiology – Animal

A couple requests blood typing of their 2-year-old child (father AB, Rh-negative; mother B, Rhnegative). Results of hemagglutination assays of the child’s blood are shown in the next figure. Which of the following conclusions concerning the child’s parentage is valid?