#Question id: 854
#Part-B Specialized Branches in Biotechnology
Many conditions including type 2 diabetes, Alzheimer disease, Huntington disease and parkinson disease are associated with the misfolding mechanism a soluble protein that is normally secreted from the cell is secreted in the missfold state and converted into an insoluble extracellular fibre the diseases are correctly referred to as
#Question id: 857
#Part-B Specialized Branches in Biotechnology
The aggregation of nonpolar side chains in the interior of a protein is favored by
#Question id: 859
#Part-B Specialized Branches in Biotechnology
Which one statement is incorrect about ATG genes;
#Question id: 861
#Part-B Specialized Branches in Biotechnology
Alexander Varshavsky discovered, the half-lives of many cytoplasmic proteins vary with the identities of their N-terminal residues via the so-called N-end rule:-
|
A. Destabilizing N-terminal residues Asp, Arg, Leu, Lys, and Phe have half-lives of |
i. Only 2 to 3 minutes, |
|
B. Stabilizing N-terminal residues Ala, Gly, Met, Ser, Thr, and Val have half-lives of |
ii. >10 hours in prokaryotes iii. >20 hours in eukaryotes. |
#Question id: 863
#Part-B Specialized Branches in Biotechnology
Ubiquitinated proteins are proteolytically degraded in an ATP-dependent process mediated by a large (∼2500 kD, 26S) multiprotein complex named the 26S proteasome;
#Question id: 865
#Part-B Specialized Branches in Biotechnology
In autophagy, the endoplasmic reticulum (ER) first gives rise to a cup-shaped, membranous cisterna called the______