Consider the following alignment of two DNA sequences:

                            AGTAAC

                            AA_ _AC

Assuming an affine gap scoring scheme of an identity matrix for substitution, a gap initiation penalty of 1 and a gap extension penalty of 0.1, the score of the alignment is _________

#Question id: 3642

#Part-A Aptitude & General Biotechnology

Any piece of DNA which replicates as a single unit is called

#Question id: 909

#Part-B Specialized Branches in Biotechnology

Most proteins denature at both high and low pH. At high pH, the ionization of internal tyrosines is thought to be the main destabilizing influence, whereas at low pH, the protonation of buried histidines. A titration curve for the unfolding of the enzyme ribonuclease is shown in Figure. Given the relation between the titration curves for protein unfolding and histidine protonation, which of the following conclusion can be drawn correctly?

A. The sharp transition in graph indicates a highly cooperative process; when the protein starts to unfold, it completes the process rapidly

B. The sharp transition in graph indicates a highly noncooperative process

C. Several buried histidines can ionize when the chain starts to unfold, so that when one goes, they all go together due to cooperative behaviour of protein folding

D. Buried histidine (pK of 4 in this example) becomes accessible to solvent, its pK will shift toward its normal value of 6, significantly steepening its titration curve.

#Question id: 5393

#Part-A Aptitude & General Biotechnology

The set of numbers (5, 6, 7, m, 6, 7, 8, n) has an arithmetic mean of 6 and mode (most frequently occurring number) of 7. Then m × n = ?

#Question id: 6562

#Part-A Aptitude & General Biotechnology

Find the wrong number in the series : 7, 28, 63, 124, 215, 342, 511 

#Question id: 10340

#Part-B Specialized Branches in Biotechnology

There several charecteristics of nitrate reductase, which of the following properties of nitrate reductase is incorrect?