Which of the following statement is true?

A) PAM matrices are derived from an evolutionary model whereas the BLOSUM matrices consist of entirely direct observations. 

B) Because of BLOSUM matrices have less evolutionary meaning that is why the PAM matrices are used most often for reconstructing phylogenetic trees.

C) BLOSUM matrices are entirely derived from local sequence alignments of conserved sequence blocks, whereas the PAM matrix is based on the global alignment of full-length sequences.

D) BLOSUM matrices are more advantageous in searching databases and finding conserved domains in proteins.

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#Question id: 12490

#Part-B Specialized Branches in Biotechnology

Tay-Sachs disease shows autosomal recessive inheritance. Parents of a newly diagnosed affected child are referred for genetic counselling. It would be correct to tell them that:

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#Question id: 12491

#Part-A Aptitude & General Biotechnology

Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12491

#Part-B Specialized Branches in Biotechnology

Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12492

#Part-A Aptitude & General Biotechnology

A young man with phenylketonuria, who was successfully treated following diagnosis on newborn screening, is planning to start a family with his healthy, unaffected, and unrelated partner, who has no family history of phenylketonuria . Phenylketonuria shows autosomal recessive inheritance with an incidence of 1 in 10 000. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12493

#Part-A Aptitude & General Biotechnology

Cystic fibrosis shows autosomal recessive inheritance with an incidence of 1 in 2500. The unaffected brother of an affected girl is referred for genetic counseling. Assume that the population is in Hardy-Weinberg equilibrium. Which of the following is correct?

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#Question id: 12494

#Part-A Aptitude & General Biotechnology

Hunter syndrome is a rare form of mucopolysacchararidosis that differs from all other forms in that it shows X-linked recessive inheritance. A woman with two affected brothers is referred for genetic counselling. Which of the following is correct?