TLS Online TPP Program

#Question id: 12496


A woman who has two brothers and a maternal uncle (her mother's brother) with non-specific X-linked mental retardation is referred for genetic counselling. There are no diagnostic tests available to help determine whether or not she is a carrier. Which of the following is correct?

#Part-A Aptitude & General Biotechnology
  1. The prior probability that she is a carrier is 1 in 4.
  2. The woman already has two unaffected sons. Therefore, the probability that she is a carrier can be calculated using Bayes' theorem to be 1 in 5.
  3. This means that the probability that her next son will be affected or that her next daughter will be a carrier is 1 in 5.
  4. The probability that the maternal grandmother of this woman is a carrier is 1 in 2.