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TLS Online TPP Program

#Question id: 12487

Neurofibromatosis type 1 is one of the most common autosomal dominant disorders. A woman with neurofibromatosis type 1 has an unaffected partner. Which of the following is correct regarding their children?

#Part-B Specialized Branches in Biotechnology
  1. The probability that each of their children will be affected is 1 in 4.
  2. The probability that their second child will be affected if their first child is affected is 1 in 4.
  3. The probability that their third child will be affected if their first two children are affected is 1 in 2.
  4. If their first child is affected then their second child will not be affected.
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TLS Online TPP Program

#Question id: 18957

#Part-A Aptitude & General Biotechnology

A DNA fragment of 5000bp needs to be isolated from E.coli (genome size 4x103kb) genomic library. The minimum number of independent recombinant clones required to represent this fragment in genomic library are
TLS Online TPP Program

#Question id: 18958

#Part-A Aptitude & General Biotechnology

The number of clones to represent this fragment in genomic library with a probability of 95% are
TLS Online TPP Program

#Question id: 18959

#Part-A Aptitude & General Biotechnology

 Vectors used for construction of genomic libraries, and their capacity is given match them correctly
A- λ EMBL series                                                                                   I - 300kb - 1,400 kb
B - Cosmids                                                                                                 II - 45 kb
C – BACs and YACs (high capacity vectors)                                             III - 20kb
TLS Online TPP Program

#Question id: 18960

#Part-A Aptitude & General Biotechnology

cDNA library do not require very large vectors hence which of the following is commonly used in cDNA library
TLS Online TPP Program

#Question id: 18961

#Part-A Aptitude & General Biotechnology

When a cDNA library is generated by first removing those mRNA or cDNA sequences that are common to two sources, e.g., two different Cell types, such a library is called 
TLS Online TPP Program

#Question id: 18962

#Part-A Aptitude & General Biotechnology

1. Presence of oncogenes (iaaM, iaaH and ipt) in T-DNA,

2. Their large size makes the handling procedures during cloning tedious and cumbersome

3. A general lack of unique cloning sites within the T-DNA, which are needed for the insertion of DNA segments to be cloned.

These three problems have been resolved by deleting