Allelic exclusion - Once allele’s functional protein is generated, rearrangement at the other allele is shut down

TLS Online TPP Program

#Id: 8160

#Section 3: Genetics, Cellular and Molecular Biology

The KDEL receptor and other membrane proteins that

are transported Golgi to ER contain 

Lys-Lys-X-X sequence at C-terminal

TLS Online TPP Program

#Id: 8159

#Section 3: Genetics, Cellular and Molecular Biology

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 8158

#Section 3: Genetics, Cellular and Molecular Biology

Soluble ER-resident proteins contain C-terminal KDEL sorting signal that allows them to be retrieved. 

TLS Online TPP Program

#Id: 8157

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8156

#Section 3: Genetics, Cellular and Molecular Biology

Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals

TLS Online TPP Program

#Id: 8154

#Section 3: Genetics, Cellular and Molecular Biology

Sar1 GTPase drives the pinching off of COPII vesicles

ARF GTPase drives the pinching off of COPIvesicles

Dynamin GTPase drives the pinching off of clathrin-coated vesicles