Allelic exclusion - Once allele’s functional protein is generated, rearrangement at the other allele is shut down

TLS Online TPP Program

#Id: 8393

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation of MLC 

unfolds the myosin II, active and can assemble into bipolar filaments for contraction

TLS Online TPP Program

#Id: 8392

#Section 3: Genetics, Cellular and Molecular Biology

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC. 

TLS Online TPP Program

#Id: 8391

#Section 3: Genetics, Cellular and Molecular Biology

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 8373

#Section 3: Genetics, Cellular and Molecular Biology

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.

TLS Online TPP Program

#Id: 8372

#Section 3: Genetics, Cellular and Molecular Biology

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 8371

#Section 3: Genetics, Cellular and Molecular Biology

In the presence of ATP,  myosin head releases from the actin filament.