Anergy versus clonal expansion

TLS Online TPP Program

#Id: 8644

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

TLS Online TPP Program

#Id: 8645

#Section 3: Genetics, Cellular and Molecular Biology

Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

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#Id: 8646

#Section 3: Genetics, Cellular and Molecular Biology

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

TLS Online TPP Program

#Id: 8647

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8648

#Section 3: Genetics, Cellular and Molecular Biology

During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

TLS Online TPP Program

#Id: 8649

#Section 3: Genetics, Cellular and Molecular Biology

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.