Regulation and function of T helper subtypes

TLS Online TPP Program

#Id: 8353

#Section 3: Genetics, Cellular and Molecular Biology

A second NPF is a large protein complex called WAVE

and requires small GTP-binding protein Rac1.

TLS Online TPP Program

#Id: 8351

#Section 3: Genetics, Cellular and Molecular Biology

WASp activation requires two signals (This type of two-signal input, called coincidence detection):

1. regulatory phospholipid PIP2

2. small GTP-binding protein Cdc42

TLS Online TPP Program

#Id: 8350

#Section 3: Genetics, Cellular and Molecular Biology

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.

TLS Online TPP Program

#Id: 8348

#Section 3: Genetics, Cellular and Molecular Biology

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)

TLS Online TPP Program

#Id: 8347

#Section 3: Genetics, Cellular and Molecular Biology

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 8346

#Section 3: Genetics, Cellular and Molecular Biology

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase