The tumor cells may acquire additional oncogenic mutations that allow them to escape the immune system.

TLS Online TPP Program

#Id: 8632

#Section 3: Genetics, Cellular and Molecular Biology

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]

TLS Online TPP Program

#Id: 8363

#Section 3: Genetics, Cellular and Molecular Biology

Myosins have 

Motor head domain

Lever-arm neck domain

Cargo-binding tail domain

TLS Online TPP Program

#Id: 7954

#Section 3: Genetics, Cellular and Molecular Biology

The precursor oligosaccharide is transferred from a

dolichol lipid anchor to the asparagine as an intact unit in a reaction catalyzed by a transmembrane oligosaccharyl transferase enzyme complex.

TLS Online TPP Program

#Id: 8342

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 7946

#Section 3: Genetics, Cellular and Molecular Biology

O-linked oligosaccharides

Carbohydrate chains in glycoproteins attached to the

hydroxyl group (-OH) in serine and threonine residues