T-dependent response

Recognition of protein antigens and requires the participation of CD4 helper T cells

TLS Online TPP Program

#Id: 10314

#Section 2: General Biology

Tumors that arise from exposure to mutagens, such as melanomas (UV light) and lung carcinomas (tobacco smoke) the number of mutations may be hundredfold greater than this. These altered proteins are known as neo-antigens

TLS Online TPP Program

#Id: 9209

#Section 3: Genetics, Cellular and Molecular Biology

Founder effect

A few individuals form a population start a new population with a different allele frequency than the original population.

Sampling error can arise is through the founder effect, which results from the establishment of a population by a small number of individuals.

TLS Online TPP Program

#Id: 8973

#Section 3: Genetics, Cellular and Molecular Biology

The current record holder is the gene Dscam in Drosophila. Alternative splicing of its 95 exons could potentially produce more than 38,000 kinds of proteins from this single gene.

TLS Online TPP Program

#Id: 10387

#Section 2: General Biology

Class I presentation requires internal synthesis of virus protein, as shown by the requirement that the target cell be infected by live virus, and by the inhibition of class I presentation observed when protein synthesis was blocked by the inhibitor emetine.

TLS Online TPP Program

#Id: 7944

#Section 3: Genetics, Cellular and Molecular Biology

Membrane and soluble secretory proteins synthesized on the rough ER undergo four principal modifications before they reach their final destinations: 

(1) Glycosylation in the ER and Golgi complex

(2) Formation of disulfide bonds in the ER

(3) Proper folding of polypeptide chains and assembly of multisubunit proteins in the ER

(4) Specific proteolytic cleavages in the ER, Golgi complex, and secretory vesicles