Nurturing Life Sciences
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#Section 3: Genetics, Cellular and Molecular Biology
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#Section 2: General Biology
The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex.
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The amino group at C-2 bears a fatty acid in amide linkage.
The fatty acid is usually saturated or monounsaturated, with 16, 18, 22, or 24 carbon atoms.
Ceramide is the parent compound for this group.
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