Anterograde transport

COPII vesicles = ER to Golgi

TLS Online TPP Program

#Id: 8191

#Section 3: Genetics, Cellular and Molecular Biology

PTS1 signals are recognized by the peroxin Pex5 receptor

PTS2 signals are recognized by the peroxin Pex7 receptor

Neither targeting sequence is cleaved after import.

TLS Online TPP Program

#Id: 8190

#Section 3: Genetics, Cellular and Molecular Biology

Peroxins

Catalyse peroxisomal protein import by ATP hydrolysis.

TLS Online TPP Program

#Id: 8189

#Section 3: Genetics, Cellular and Molecular Biology

C-terminal peroxisomal signal sequences Ser–Lys–Leu (PTS1)

N-terminal peroxisomal signal sequences slightly longer and partially hydrophobic (PTS2)

TLS Online TPP Program

#Id: 8188

#Section 3: Genetics, Cellular and Molecular Biology

Plasmalogens

• most abundant class of PL in myelin sheaths

• Analogous to PC

• Contain an unusual fatty alcohol that is attached through an ether linkage.

TLS Online TPP Program

#Id: 8187

#Section 3: Genetics, Cellular and Molecular Biology

Biosynthetic function of animal peroxisomes- 

Synthesis of cholesterol and dolichol 

Synthesis of bile acids in the liver 

Catalyze the first reactions in the formation of Plasmalogens

TLS Online TPP Program

#Id: 8186

#Section 3: Genetics, Cellular and Molecular Biology

Glyoxysomes

Conversion of fats to sugars is accomplished by a series of reactions known as the Glyoxylate cycle