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TLS Online TPP Program

#Id: 8333

Jasplakinolide,
a sponge toxin, enhances nucleation by binding and stabilizing actin dimers and lowering the Cc.

#Section 3: Genetics, Cellular and Molecular Biology #MICROFILAMENTS #Part B Pointers
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TLS Online TPP Program

#Id: 8645

#Section 3: Genetics, Cellular and Molecular Biology

Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.
TLS Online TPP Program

#Id: 8646

#Section 3: Genetics, Cellular and Molecular Biology

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.
TLS Online TPP Program

#Id: 8647

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8648

#Section 3: Genetics, Cellular and Molecular Biology

During exit from mitosis and G1, 
Cdh1 is de-phosphorylated and APC/Ccdh1 is active.
TLS Online TPP Program

#Id: 8649

#Section 3: Genetics, Cellular and Molecular Biology

During S phase and mitosis, 
Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.
TLS Online TPP Program

#Id: 8650

#Section 3: Genetics, Cellular and Molecular Biology

G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition