Actin filament treadmilling is accelerated by:

Profilin and Cofilin

TLS Online TPP Program

#Id: 8524

#Section 3: Genetics, Cellular and Molecular Biology

Detyrosylation 

tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits. 

TLS Online TPP Program

#Id: 8523

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8522

#Section 3: Genetics, Cellular and Molecular Biology

Lysine acetylation 

ε-amino group of a specific lysine of α-tubulin

Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)

TLS Online TPP Program

#Id: 8521

#Section 3: Genetics, Cellular and Molecular Biology

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.

TLS Online TPP Program

#Id: 8520

#Section 3: Genetics, Cellular and Molecular Biology

Post-translational modifications of tubulin:

Lysine acetylation

Detyrosylation

Polyglutamylation

Polyglycylation

TLS Online TPP Program

#Id: 8519

#Section 3: Genetics, Cellular and Molecular Biology