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TLS Online TPP Program

#Id: 8540

Dynein-related transport requires dynactin, that links dynein to its cargo

#Section 3: Genetics, Cellular and Molecular Biology #Microtubules #Part B Pointers
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TLS Online TPP Program

#Id: 8348

#Section 3: Genetics, Cellular and Molecular Biology

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)
TLS Online TPP Program

#Id: 8347

#Section 3: Genetics, Cellular and Molecular Biology

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)
TLS Online TPP Program

#Id: 8346

#Section 3: Genetics, Cellular and Molecular Biology

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase
TLS Online TPP Program

#Id: 8345

#Section 3: Genetics, Cellular and Molecular Biology
TLS Online TPP Program

#Id: 8343

#Section 3: Genetics, Cellular and Molecular Biology

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly
TLS Online TPP Program

#Id: 8342

#Section 3: Genetics, Cellular and Molecular Biology