Phosphorylation of a critical threonine residue in the activation loop, Thr-160, allowing substrates to access the active site of the CDK

TLS Online TPP Program

#Id: 10372

#Section 2: General Biology

TLS Online TPP Program

#Id: 8053

#Section 2: General Biology

1. Alanine is can be mutated to

TLS Online TPP Program

#Id: 10330

#Section 2: General Biology

The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 8162

#Section 3: Genetics, Cellular and Molecular Biology

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 9152

#Section 3: Genetics, Cellular and Molecular Biology

Inbreeding

Preferential mating between related individuals.

Inbreeding is more likely to take place in nature when population size becomes very small, and the number of mates is limited.