A second class of CKIs found in metazoan cells is the Cip/Kip family of CKIs, consists of three proteins—p21CIP, p27KIP1, and p57KIP2. 

TLS Online TPP Program

#Id: 8171

#Section 3: Genetics, Cellular and Molecular Biology

In mammalian cells, Rab5 protein (early endosomes) and its effector protein known as EEA1 (early endosome antigen 1)

TLS Online TPP Program

#Id: 8871

#Section 3: Genetics, Cellular and Molecular Biology

Until Mitotic CDKs is not active, the activatory protein phosphatase, Cdc25, is phosphorylated, bound and inhibited by phosphoserine/threonine-binding protein 14-3-3.

TLS Online TPP Program

#Id: 8644

#Section 3: Genetics, Cellular and Molecular Biology

Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

TLS Online TPP Program

#Id: 8628

#Section 3: Genetics, Cellular and Molecular Biology

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8884

#Section 3: Genetics, Cellular and Molecular Biology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.