Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

TLS Online TPP Program

#Id: 8881

#Section 3: Genetics, Cellular and Molecular Biology

Plk1 is critical for formation of the mitotic spindle as well as for chromosome segregation.

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#Id: 8882

#Section 3: Genetics, Cellular and Molecular Biology

The Aurora kinase family members Aurora A and Aurora B play key roles in mitotic spindle formation and in ensuring that chromosomes attach correctly to the mitotic spindle so that they are segregated accurately during mitosis.

TLS Online TPP Program

#Id: 8883

#Section 3: Genetics, Cellular and Molecular Biology

Once mitotic CDKs are activated at the end of G2 , they phosphorylate specific serine residues in all 3 nuclear lamins.

TLS Online TPP Program

#Id: 8884

#Section 3: Genetics, Cellular and Molecular Biology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.

TLS Online TPP Program

#Id: 8885

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8886

#Section 3: Genetics, Cellular and Molecular Biology