Geminin is expressed in late G1; it binds to and inhibits Cdt1 preventing reloading of the MCM helicase.

TLS Online TPP Program

#Id: 8152

#Section 3: Genetics, Cellular and Molecular Biology

After the vesicle coat is complete, the Sec23 coat subunit promotes GTP hydrolysis causes disassembly of the coat.

TLS Online TPP Program

#Id: 8151

#Section 3: Genetics, Cellular and Molecular Biology

Sec12

acts as a GEF factor for Sar1

TLS Online TPP Program

#Id: 8150

#Section 3: Genetics, Cellular and Molecular Biology

Sar1 is the only GTPase switch protein activated at the ER membrane

TLS Online TPP Program

#Id: 8149

#Section 3: Genetics, Cellular and Molecular Biology

ARF and Sar1 similar to Ras

TLS Online TPP Program

#Id: 8148

#Section 3: Genetics, Cellular and Molecular Biology

Depolymerization of the clathrin coat into triskelions  by Cytosolic Hsp70

TLS Online TPP Program

#Id: 8147

#Section 3: Genetics, Cellular and Molecular Biology

A clathrin molecule,

called a triskelion, is composed of : 

Three heavy chains

Three light chains