The phosphorylation state of T14 and Y15 is controlled by a dual-specificity protein kinase known as Wee1 and a pair of dual-specificity phosphatases, Cdc25B and Cdc25C (Threonine 14 is not phosphorylated in S. pombe CDK1)

TLS Online TPP Program

#Id: 10328

#Section 2: General Biology

Engineering T Cells to Recognize Tumor Antigens

When reactivated by inhibition of the immune checkpoint, have the capacity to recognize and kill some tumors with a large burden of mutations.

TLS Online TPP Program

#Id: 10329

#Section 2: General Biology

Binding of the extracellular TCR domain to a MHC-peptide complex triggers activation of ZAP70 protein tyrosine kinases attached to the cytosolic domains of the two adjacent ζ chains. 

TLS Online TPP Program

#Id: 10330

#Section 2: General Biology

The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 10331

#Section 2: General Biology

TLS Online TPP Program

#Id: 10332

#Section 2: General Biology

TLS Online TPP Program

#Id: 10333

#Section 2: General Biology