The Aurora kinase family members Aurora A and Aurora B play key roles in mitotic spindle formation and in ensuring that chromosomes attach correctly to the mitotic spindle so that they are segregated accurately during mitosis.

TLS Online TPP Program

#Id: 8165

#Section 3: Genetics, Cellular and Molecular Biology

TANGO1 is an ER membrane protein that acts as a cargo receptor for collagen.

TLS Online TPP Program

#Id: 8164

#Section 3: Genetics, Cellular and Molecular Biology

Vesicles coated with GGA proteins and clathrin bind to proteins containing 

Asp-X-Leu-Leu and Asp-Phe-Gly-X-Φ sequences

TLS Online TPP Program

#Id: 8163

#Section 3: Genetics, Cellular and Molecular Biology

Vesicles coated with AP1 and clathrin bind to  proteins containing a Tyr-X-X-Φ sequence

TLS Online TPP Program

#Id: 8162

#Section 3: Genetics, Cellular and Molecular Biology

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 8161

#Section 3: Genetics, Cellular and Molecular Biology

KKXX sorting signal,

binds to a complex of the COPI α and β subunits

TLS Online TPP Program

#Id: 8160

#Section 3: Genetics, Cellular and Molecular Biology

The KDEL receptor and other membrane proteins that

are transported Golgi to ER contain 

Lys-Lys-X-X sequence at C-terminal