Founder effect

A few individuals form a population start a new population with a different allele frequency than the original population.

Sampling error can arise is through the founder effect, which results from the establishment of a population by a small number of individuals.

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A given MHC molecule can bind numerous different peptides, and some peptides can bind to several different MHC molecules. Because of this MHC molecule is often referred to as “promiscuous”.

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MHC-Peptide Interaction

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One individual, however, expresses only a small number of these molecules—up to six different class I molecules and 12 or more different class II molecules.

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MHC molecules in mouse