THE MAGNITUDE OF GENETIC DRIFT

n  = population size

pq=allelic frequency

sp2=variance in allelic frequency among the populations

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In yeast Rab protein is the Sec4 and its effectors are exocyst and Type V Myosin.

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#Section 3: Genetics, Cellular and Molecular Biology

Rab·GTP is enabled to bind to a variety of different proteins, known as Rab effectors.

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#Section 3: Genetics, Cellular and Molecular Biology

Rab GTPases 

associate with transport vesicles and act as key regulators of vesicle trafficking to and fusion with the appropriate target membrane.

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Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

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CFTR protein contains

a di-acidic sorting signal that binds to the Sec24 subunit

of the COPII vesicle coat and is necessary for transport of

the CFTR protein out of the ER.

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#Section 3: Genetics, Cellular and Molecular Biology

TANGO1 is an ER membrane protein that acts as a cargo receptor for collagen.