TLS Online TPP Program

#Id: 8343

#Section 3: Genetics, Cellular and Molecular Biology

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8342

#Section 3: Genetics, Cellular and Molecular Biology

TLS Online TPP Program

#Id: 8341

#Section 3: Genetics, Cellular and Molecular Biology

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

TLS Online TPP Program

#Id: 8340

#Section 3: Genetics, Cellular and Molecular Biology

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.

TLS Online TPP Program

#Id: 8339

#Section 3: Genetics, Cellular and Molecular Biology

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end

TLS Online TPP Program

#Id: 8338

#Section 3: Genetics, Cellular and Molecular Biology

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.