TLS Online TPP Program

#Question id: 12182


The cell cycle is controlled by protein kinases that comprise a catalytic subunit and a regulatory subunit. Which of the following statement is correct regarding to these subunits?

#Section 3: Genetics, Cellular and Molecular Biology
  1. The catalytic subunits, the cyclin-dependent kinases (CDKs), have no kinase activity unless they are dissociated with a regulatory cyclin subunit. 
  2. Each CDK can associate with a small number of different cyclins, which determine the substrate specificity of the complex—that is, which proteins it phosphorylates.
  3. Cyclin-CDK complexes activate or inhibit hundreds of proteins involved in cell cycle progression by phosphorylating or dephosphorylating them at specific regulatory sites. 
  4. Proper progression through the cell cycle is governed by activation of the appropriate homodimeric protein kinase complex at the appropriate time.