The phosphorylated Ci is proteolytically cleaved by the ubiquitin-proteasome pathway, generating an N-terminal fragment Ci75, which functions as a transcriptional repressor of Hh target genes.

TLS Online TPP Program

#Id: 10641

#XL - R Botany

Family - Musaceae

( Banana Family )

Floral formula & Diagram

TLS Online TPP Program

#Id: 8646

#XL - T Zoology

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

TLS Online TPP Program

#Id: 9459

#XL - T Zoology

Ligand binding triggers a conformational change in the JAKs & they phosphorylate each other on a critical tyrosine in the activation loop which greatly enhances kinase activity

TLS Online TPP Program

#Id: 10383

#XL - Q Biochemistry

Corticosteroids and prostaglandins can also decrease expression of class II MHC molecules.

TLS Online TPP Program

#Id: 10026

#XL - T Zoology

NF-κB pathway is activated by:

TNFα and IL-1, released by immune cells in response to infection.