An E3 ubiquitin ligase binds to Phosphoserines of I-κBα & links poly-K48-linked ubiquitin chains that target the attached I-κBα protein to the proteasomal degradation

TLS Online TPP Program

#Id: 8645

#XL - R Botany

Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

TLS Online TPP Program

#Id: 8646

#XL - R Botany

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

TLS Online TPP Program

#Id: 8647

#XL - R Botany

TLS Online TPP Program

#Id: 8648

#XL - R Botany

During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

TLS Online TPP Program

#Id: 8649

#XL - R Botany

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#XL - R Botany

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition