Three classes of classical cadherins: 

E-cadherin -present on epithelial cells

N-cadherin - present on nerve, muscle and lens cells

P-cadherin - present on cells in the placenta & epidermis

TLS Online TPP Program

#Id: 8880

#XL - T Zoology

Active cytoplasmic cyclin B-CDK1 translocates into the nucleus, where it phosphorylates nuclear lamins to cause nuclear envelope breakdown and, together with Plk1 and the Aurora kinases, induces chromosome condensation and formation of the mitotic spindle.

TLS Online TPP Program

#Id: 8881

#XL - T Zoology

Plk1 is critical for formation of the mitotic spindle as well as for chromosome segregation.

TLS Online TPP Program

#Id: 8882

#XL - T Zoology

The Aurora kinase family members Aurora A and Aurora B play key roles in mitotic spindle formation and in ensuring that chromosomes attach correctly to the mitotic spindle so that they are segregated accurately during mitosis.

TLS Online TPP Program

#Id: 8883

#XL - T Zoology

Once mitotic CDKs are activated at the end of G2 , they phosphorylate specific serine residues in all 3 nuclear lamins.

TLS Online TPP Program

#Id: 8884

#XL - T Zoology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.

TLS Online TPP Program

#Id: 8885

#XL - T Zoology