Three classes of classical cadherins: 

E-cadherin -present on epithelial cells

N-cadherin - present on nerve, muscle and lens cells

P-cadherin - present on cells in the placenta & epidermis

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Resistance to leishmaniasis correlates well with the production of IFN-ϒ and the development of a TH1 response.

Strains of mice that are naturally resistant to Leishmania develop a TH1 response and produce IFN-ϒ upon infection. 

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Parasitic Worms (Helminths) Typically Generate Weak Immune Responses

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Natural immunity to helminth infections is Th2-type responses, including ILC2s, and IL-4 and IgE production.

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Immune Response Generated against Schistosoma mansoni

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Fungal disease

The barriers of innate immunity control most fungi.

Phagocytosis by neutrophils is a strong defense against most fungi

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