The binding of integrins to their ligands depends on extracellular divalent cations(Ca+2 & Mg+2)

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#Id: 10045

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In Notch/Delta pathway, 

Notch is receptor protein, on a neighboring responding cell

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In the absence of Delta, 

TM subunit of Notch on the surface of a responding cell is non-covalently associated with its extracellular subunit; extracellular domain is folded

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Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

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ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.

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#Id: 10049

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ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)

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#Id: 10050

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Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell