Outside-in signaling

Binding of integrins to their ligands induces conformational changes in their cytoplasmic domains, directly or indirectly altering their interactions with cytoplasmic proteins

TLS Online TPP Program

#Id: 9446

#XL - T Zoology

The cytokines form a family of relatively small, secreted signaling molecules:

Contain about 160–200 AA

4 long, conserved α helices

Control growth and differentiation

TLS Online TPP Program

#Id: 9202

#XL - T Zoology

Disruptive Natural selection

Disruptive selection favors the survival of individuals at both extremes of a range, rather than the  intermediate.

Increase variance in the population because select those phenotype which are away from mean.

It maintain balance polymorphism and maximum selection coefficient value.

TLS Online TPP Program

#Id: 8162

#XL - Q Biochemistry

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 8650

#XL - R Botany

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

TLS Online TPP Program

#Id: 9876

#XL - T Zoology

These epithelial barriers include the skin and the tissue surfaces connected to the body’s openings.

Skin and other epithelia provide a kind of living “plastic wrap” that encases and protects the inner domains of the body from infection.