Integrin exist in two conformations: 

Inactive, low-affinity, “bent” conformation  

Active, high-affinity, “extended” conformation

TLS Online TPP Program

#Id: 9705

#XL - T Zoology

The receptors for yeast α and a mating factors are coupled to the same trimeric G protein.

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#Id: 9706

#XL - T Zoology

Ligand binding to either of the two yeast pheromone GPCRs triggers the exchange of GTP for GDP on the Gα subunit and dissociation of Gα∙GTP from the Gβγ complex.

TLS Online TPP Program

#Id: 9707

#XL - T Zoology

Ligand binding and dissociation of the G protein subunits, the membrane-tethered Gβγ subunit binds the Ste5.

TLS Online TPP Program

#Id: 9708

#XL - T Zoology

Ste5 acts as a scaffold for assembling other components in the cascade Ste11, Ste7, and Fus3.

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#Id: 9709

#XL - T Zoology

Gβγ activates Cdc24, a GEF for Cdc42

TLS Online TPP Program

#Id: 9710

#XL - T Zoology

Cdc24 = SOS

Cdc42 = Ras