TLS Online TPP Program

#Id: 10059

#XL - T Zoology

Heterophilic Binding

A CAM on one cell can directly bind to a different class of CAM on an adjacent cell

TLS Online TPP Program

#Id: 10060

#XL - T Zoology

The formation of many cell-cell adhesions entails two types of molecular interactions:

1.Trans binding interactions 

2. Cis binding interactions

TLS Online TPP Program

#Id: 10061

#XL - T Zoology

Trans interactions (intercellular or adhesive interactions)

CAMs on one cell bind to CAMs on an adjacent cell. 

TLS Online TPP Program

#Id: 10062

#XL - T Zoology

In cis interactions (intracellular or lateral interactions)

monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane

TLS Online TPP Program

#Id: 10063

#XL - T Zoology

CAMs fall into one of four major families: 

Cadherins

Immunoglobulin (Ig) superfamily

Integrins

Selectins

TLS Online TPP Program

#Id: 10064

#XL - T Zoology

The adhesiveness of cadherins depends on the presence of extracellular Ca2+