Class I MHC, glycoproteins expressed on the surface of nearly all nucleated cells; the major function of the class I is presentation of endogenous peptide antigens to CD8+ T cells.

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In cells, PI-3 kinase pathway :

Triggers cell division 

Prevents apoptosis

Induces specific changes in cell metabolism

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An important signal transduction protein that binds to PI 3-phosphates is protein kinase B (Akt),  a serine/threonine kinase

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PI-3 kinase was first identified in studies of the 

polyoma virus, a DNA virus

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PKB contains:

A PH domain

A kinase domain

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PH domain of PKB binds with high affinity to the 

3-phosphates in both PI(3,4)P2 and PI(3,4,5)P3

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In unstimulated cells, 

concentration of phosphoinositides is low, and PKB is

inactive because its PH domain physically blocks the kinase active site