Family - Faba/ Papilionaceae

( Pea Family )

Floral formula & Diagram

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The promoter or enhancer segments of all genes regulated by PKA contain a cis-acting DNA sequence, the cAMP-response element (CRE), which

contains the highly conserved nucleotide sequence,

5'-TGACGTCA-3'.

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In nucleus PKA phosphorylate serine-133 on a transcription factor called CREbinding (CREB) protein

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Phosphorylated CREB binds to CRE-containing target genes and also binds to the co-activator termed CBP/P300, thereby stimulating gene transcription

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Inactive PKA is a tetramer consisting of- 

two regulatory (R) subunits

two catalytic (C) subunits

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Two large classes of GTPase switch proteins are used in signal transduction pathways:

1. Heterotrimeric G proteins

2. Monomeric G proteins