Permanent tissue

It can be simple, complex or specialized

Cells donot divide further

Cell wall of its cells may either thin or thick

Intercellular spaces are often present

TLS Online TPP Program

#Id: 10013

#XL - T Zoology

In the absence of Hh,

Ptc inhibits Smoothened and then degraded in proteasomes

TLS Online TPP Program

#Id: 10014

#XL - T Zoology

Transcription Factor

zinc-finger transcription factor Cubitis interruptus

TLS Online TPP Program

#Id: 10015

#XL - T Zoology

A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

TLS Online TPP Program

#Id: 10016

#XL - T Zoology

Cytosolic complex is bound to a microtubule by the kinesin-related motor protein Costal-2 (Cos2).

TLS Online TPP Program

#Id: 10017

#XL - T Zoology

In this complex, Ci becomes phosphorylated in a series of steps catalyzed by PKA, GSK3β, and CK1.

TLS Online TPP Program

#Id: 10018

#XL - T Zoology

The phosphorylated Ci is proteolytically cleaved by the ubiquitin-proteasome pathway, generating an N-terminal fragment Ci75, which functions as a transcriptional repressor of Hh target genes.