Permanent tissue

It can be simple, complex or specialized

Cells donot divide further

Cell wall of its cells may either thin or thick

Intercellular spaces are often present

TLS Online TPP Program

#Id: 10038

#XL - T Zoology

After dimerization MyD88 proteins bind to the IL-1R through the TIRs, and facilitates the binding of many copies of the kinases IRAK4 and IRAK1 or IRAK2

TLS Online TPP Program

#Id: 10039

#XL - T Zoology

Activated IRAK1/2, binds TRAF6, an E3 ubiquitin ligase, to the signalsome, and promotes the formation of an extended 2-D lattice formed by TRAF6-TRAF6 interactions.

TLS Online TPP Program

#Id: 10040

#XL - T Zoology

TRAF6 catalyzes synthesis of long K-63-linked polyubiquitin chains that are covalently linked to TRAF6 itself.

TLS Online TPP Program

#Id: 10041

#XL - T Zoology

Rather than degradation, poly-K63 ubiquitin chains act as scaffolds that bind proteins that have a poly-K63 ubiquitin-binding domain

TLS Online TPP Program

#Id: 10042

#XL - T Zoology

Poly-K63 ubiquitin-binding domain containing proteins:

Protein kinase TAK1

NEMO subunit of the I-κB kinase

TLS Online TPP Program

#Id: 10043

#XL - T Zoology

Poly-K63 ubiquitin chain brings TAK1 kinase and β subunit of I-κB

kinase, into close proximity so that TAK1 can phosphorylate and activate I-κB kinase