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RAS is a small monomeric G-proteins.

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Gradualism is Darwin’s proposition that the differences between even radically different organisms have evolved by small steps through intermediate forms, not by leaps

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Wnt/PCP signaling 
Functions to regulate the actin and microtubule cytoskeleton, & influences cell shape and behaviour (migration).

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Yeast cells with a defective wee1+ gene activate mitotic CDKs prematurely and premature entry into mitosis (smaller than normal cells

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Membranes of late endosomes and lysosomes contain V-class proton pumps that act in concert with Cl- channels to acidify the vesicle lumen.

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