The SH2 domain binds strongly to any peptide containing a critical four-residue core sequence:  phosphotyrosine–glutamic acid–glutamic acid–isoleucine

TLS Online TPP Program

#Id: 9381

#XL - T Zoology

TLS Online TPP Program

#Id: 10726

#XL - R Botany

TLS Online TPP Program

#Id: 9720

#XL - T Zoology

Activated Ste12, induces expression of proteins

involved in mating-specific cellular responses.

TLS Online TPP Program

#Id: 8218

#XL - Q Biochemistry

Sorting signal that directs lysosomal hydrolases from the TGN to the late endosome is- Mannose 6-phosphate (M6P).

TLS Online TPP Program

#Id: 7914

#XL - Q Biochemistry

Matrix-targeting sequences

Located at the N-terminus

Usually 20–50 amino acids in length

Rich in hydrophobic amino acids, positively charged basic amino acids (arginine & lysine), and hydroxylated ones (serine and threonine)

Amphipathicity of matrix-targeting sequences is critical to their function