Reciprocal altruism

Cases of altruism are known to exist between unrelated individuals. What drives this phenomenon is a “You scratch my back, I’ll scratch yours” behavior called reciprocal altruism.

TLS Online TPP Program

#Id: 8225

#XL - Q Biochemistry

Hurler’s disease- mutation in a structural gene that codes for an individual lysosomal hydrolase.

TLS Online TPP Program

#Id: 8224

#XL - Q Biochemistry

Lysosomal storage diseases:

• Hurler’s disease

• Inclusion-cell disease

TLS Online TPP Program

#Id: 8223

#XL - Q Biochemistry

Retromer

a coat protein complex specialized for endosome-to-TGN transport, recycle the M6P receptor to the TGN

TLS Online TPP Program

#Id: 8221

#XL - Q Biochemistry

The M6P receptor protein binds to M6P at pH 6.5–6.7 in the TGN lumen and releases it at pH 6, in the lumen of endosomes.

TLS Online TPP Program

#Id: 8219

#XL - Q Biochemistry

M6P residues are generated in the cis-Golgi by two Golgi-resident enzymes. 

1. N-acetylglucosamine (GlcNAc) phosphotransferase
2. Phosphodiesterase

TLS Online TPP Program

#Id: 8218

#XL - Q Biochemistry

Sorting signal that directs lysosomal hydrolases from the TGN to the late endosome is- Mannose 6-phosphate (M6P).