Lineweaver-Burk plot showing the effect of uncompetitive inhibition; (b) the same, showing plots for several inhibitor concentrations at fixed enzyme concentration.

TLS Online TPP Program

#Id: 1343

#XL - T Zoology

RAS is a small monomeric G-proteins.

TLS Online TPP Program

#Id: 1344

#XL - T Zoology

RAS is connected to the membrane by a prenylated (lipid) tail.

TLS Online TPP Program

#Id: 1345

#XL - T Zoology

All Ras have the CAAX motifs at the C-terminus.

TLS Online TPP Program

#Id: 1346

#XL - T Zoology

Post-translational modifications of the CAAX motifs determine the subcellular localization and correct biological function of Ras proteins.

TLS Online TPP Program

#Id: 1347

#XL - T Zoology

SOS – Ras GEF

NF1 - Ras GAP

TLS Online TPP Program

#Id: 1348

#XL - T Zoology

RasD or RasONC  Replacement of the normal glycine 12 with any other amino acid (except proline) “locks” Ras in the active GTP-bound state.