Chevalier de Lamarck - Inheritance of acquired characteristics

TLS Online TPP Program

#Id: 10286

#XL - Q Biochemistry

T cells initiate the adaptive immune response by interacting MHC on antigen-presenting cells that have been exposed to pathogens. 

TLS Online TPP Program

#Id: 10287

#XL - Q Biochemistry

T-Cell - Cells leaving the thymus are functional, mature T cells expressing unique and specific T-cell receptors (TCRs) that are both tolerant to self and restricted to self-MHC.

TLS Online TPP Program

#Id: 10288

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 10289

#XL - Q Biochemistry

T-cell lineage

TLS Online TPP Program

#Id: 10290

#XL - Q Biochemistry

T-Cell Development

1.Commitment

2.antigen receptor gene rearrangements

3.The selection and expansion of cells (β-selection

TLS Online TPP Program

#Id: 10291

#XL - Q Biochemistry

The second phase of T-cell development

1.Positive selection: Selection for those cells whose T-cell receptors engage self-MHC.

2.Negative selection: Selection against those cells whose T-cell receptors bind too strongly to self-peptide/MHC combinations.

3.Lineage commitment: Commitment of thymocytes to effector cell lineages, including CD4 helper or CD8 cytotoxic populations