The SRP and the nascent polypeptide chain–ribosome complex bind to the SRP receptor in the ER membrane. This interaction is strengthened by the binding of GTP to both the SRP and its receptor.

TLS Online TPP Program

#Id: 8515

#XL - Q Biochemistry

Kinesin-1 

is regulated by a 

head-to-tail interaction

TLS Online TPP Program

#Id: 8514

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8415

#XL - Q Biochemistry

Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene

TLS Online TPP Program

#Id: 8414

#XL - Q Biochemistry

Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin. 

TLS Online TPP Program

#Id: 8413

#XL - Q Biochemistry

Troponin C is closely related to the ubiquitous 

Ca2+-binding protein calmodulin

TLS Online TPP Program

#Id: 8412

#XL - Q Biochemistry

Binding of Ca2+ ions to TN-C

triggers movement of TM to a new position on the filament, thereby exposing the myosin-binding sites on actin.