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The SRP and the nascent polypeptide chain–ribosome complex bind to the SRP receptor in the ER membrane. This interaction is strengthened by the binding of GTP to both the SRP and its receptor.

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

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Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

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