The precursor oligosaccharide is transferred from a

dolichol lipid anchor to the asparagine as an intact unit in a reaction catalyzed by a transmembrane oligosaccharyl transferase enzyme complex.

TLS Online TPP Program

#Id: 8350

#XL - Q Biochemistry

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.

TLS Online TPP Program

#Id: 8348

#XL - Q Biochemistry

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)

TLS Online TPP Program

#Id: 8347

#XL - Q Biochemistry

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 8346

#XL - Q Biochemistry

Formins are activated by membrane-bound Rho-GTP, a Ras-related small GTPase

TLS Online TPP Program

#Id: 8345

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8343

#XL - Q Biochemistry

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly