The efficient formation of disulfide bonds in the lumen of the ER depends on the enzyme protein disulfide isomerase (PDI), which is present in all eukaryotic cells

TLS Online TPP Program

#Id: 9478

#XL - T Zoology

SOCS box, 

Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome

TLS Online TPP Program

#Id: 9479

#XL - T Zoology

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

TLS Online TPP Program

#Id: 9481

#XL - T Zoology

TLS Online TPP Program

#Id: 9608

#XL - T Zoology

For most, but not all, RTKs, the weakly active kinase in each subunit is phosphorylate a key tyrosine in the activation loop of the other subunit (trans-phosphorylation)

TLS Online TPP Program

#Id: 9609

#XL - T Zoology

Phosphorylation leads to a conformational change in the activation loop that unblocks kinase active site by reducing the Kd for ATP or the substrate to be phosphorylated.

TLS Online TPP Program

#Id: 9610

#XL - T Zoology

Insulin receptor, form disulfide-linked dimers in the absence of hormone.