TLS Online TPP Program

#Id: 8750

#XL - T Zoology

The lack of an ordered structure can facilitate a kind of functional promiscuity, allowing one protein to interact with multiple partners. Some intrinsically disordered proteins act to inhibit the action of other proteins by an unusual mechanism: wrapping around their protein targets.

TLS Online TPP Program

#Id: 8751

#XL - T Zoology

The protein p27 is intrinsically disordered. It wraps around and inhibits the action of several enzymes called protein kinases that facilitate cell division. 

TLS Online TPP Program

#Id: 8752

#XL - T Zoology

Predictor of Natural Disordered Regions or PONDR is one of the best available algorithms for predicting the likelihood that a given amino acid residue is in a region of intrinsic disorder, based on the surrounding amino acid sequence and amino acid composition. 

TLS Online TPP Program

#Id: 8753

#XL - T Zoology

A PONDR score of 1.0 indicates a probability of 100% that a protein will be disordered.

TLS Online TPP Program

#Id: 8754

#XL - T Zoology

The mammalian protein p53 also have both structured and unstructured segments. With its unstructured region at the carboxyl terminus four different proteins.

TLS Online TPP Program

#Id: 8755

#XL - T Zoology

Thermodynamic measurements indicate that native proteins are only marginally stable under physiological conditions. The free energy required to denature them is ∼0.4 kJ ∙ mol−1 per amino acid residue.